Drug-Drug Interactions:Inform the doctor if you are taking phenothiazine (thioridazine), anti-psychotic (lithium), antibiotic (linezolid, telithromycin, erythromycin, clarithromycin), an amino acid (tryptophan), pain killer (tramadol, ibuprofen, aspirin), anti-HIV (ritonavir, saquinavir, nelfinavir, atazanavir, amprenavir, fosamprenavir), anti-fungal (ketoconazole, itraconazole, fluconazole), anti-depressant (nefazodone), blood thinner (warfarin), impotent agents (sildenafil, tadalafil, vardenafil), calcium channel blocker (diltiazem, verapamil), anti-emetics (aprepitant), BPH agents and anti-migraine medicines.

Drug-Food Interactions:Do not take St. John’s wort (herbal supplement used to treat depression) while taking Dapoxetine. Avoid consuming grapefruit juice within 24 hours of taking Dapoxetine as it could lead to an increase in the level of Dapoxetine in the body.

Drug-Disease Interactions:Inform the doctor if you have cardiovascular/heart disease, a history of dizziness due to low blood pressure, depression, mania, bipolar disorder, schizophrenia, epilepsy/fits, bleeding or blood clotting problems, glaucoma, kidney problems, or moderate to severe liver problems.

Appropriate medical advice is required from the doctor before taking Dapoxetine. Dapoxetine is not recommended for use in children.

Appropriately compounded into prescribed dosage form

Use of St. John's wort in pregnancy and whilst taking Dapoxetine in pregnancy is not recommended.

Consult your doctor immediately if you have any symptoms of dizziness or fainting symptoms.

Consult your doctor immediately if you have any symptoms of kidney problems such as increased urination or blood in the urine.

Description of Priligy (dapoxetine)

Priligy (dapoxetine) is the first and only prescription medicine licensed to treat Premature Ejaculation (PE). It is from a class of drugs called Selective Serotonin Uptake Inhibitors (SSRIs) and can help delay ejaculation and increase control. Serotonin is a neurotransmitter in the central nervous system that plays a role in transmitting messages between nerve cells. Including those that result in ejaculation. By increasing the availability of serotonin between nerve cells the time taken to ejaculate is increased and control over ejaculation is improve.

How do I take Priligy?

One Priligy tablet should be taken between 1-3 hours of having sex.

The recommended starting dose of Priligy is 30mg no more than once in a 24-hour period.

If the 30mg dose is not effective for you your doctor may increase your dose to 60mg.

The tablet can be taken with or without food and should be swallowed whole with water.

Warnings of Use

This medication is not suitable for you if any of the following apply: You have not been diagnosed with prem mature ejaculation You also have another sexual problem, such as erectile dysfunction You have a history of dizziness from low blood pressure You use recreational drugs such as ecstasy, LSD, narcotics or benzodiazepines You have ever had a mental health problem such as depression, mania (symptoms include feeling over-excited, irritable or not being able to think clearly), bipolar disorder (symptoms include serious mood swings between mania and depression) or schizophrenia (a psychiatric disease) You have epilepsy You have a history of bleeding or blood clotting problems You have kidney problems You have, or are at risk of high pressure in the eye (glaucoma).

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Seek medical professional advice before taking this medication.

Seek medical professional medical attention if you have any problemsún a high blood pressure you have a heart problem you have liver problems you have any other health problems You have an infection You have a serious disease for which you have been prescribed (see 'Premature ejaculation' in the text).

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Do not take Priligy if you are already taking any of the following medications: Sildenafil (as-needed), tadalafil (e-gel), vardenafil (l-lysine), Dapoxetine (dapoxetine), other anti-ED medications, such as etac ptsediva (a blood-pressure medication), loratainat (a herb used to treat alopecia), paroxetine (a drug to treat depression), sildenafil (as a mood-stabilizing medicine), cimetidine (a drug to reduce swelling), warfarin (an anticoagulant) or any other blood pressure medication. Speak to your doctor about taking Priligy if you are taking any of the following medications: Spun cream or gel to treat PE you use to numb the face you may need to use a but it may take some time to be applied to the skin. If prescribed as a medicine for premature ejaculation speak to your doctor as soon as you get the opportunity to take Priligy. Priligy tablets are usually taken on an as-needed basis 1-3 hours before sex. Avoid alcohol as it can increase the risk of dizziness and side effects.

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This medication is not approved for use in children below 18 years.

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The data from clinical trials with Priligy have been available. From our experience it has been our clinical trial experience where we have had only a mild effect on control of sexual symptoms. From our experience it has been our experience that use of this medication will not only affect your sexual problems but will also affect your control over ejaculation.

The active ingredients in this medication are dapoxetine and the active ingredients in the brand name Priligy.

From our experience it has been our that sexual problems have been reduced with Priligy and sexual activity has been affected by the use of this medication.

Uses of Dapoxetine+Tadalafil

The combination of Dapoxetine + Tadalafil is used to improve blood supply to the penis and enhance its functions.

Therapeutic Category

Dapoxetine: Selective serotonin reuptake inhibitors

Tadalafil: Phosphodiesterase type 5 (PDE5) inhibitors

How Dapoxetine+Tadalafil works

Dapoxetine is a selective serotonin reuptake inhibitor. It is believed to promote control over penile functions by increasing the activity of a particular chemical called serotonin in the brain. Tadalafil is a PDE5 inhibitor. It relaxes the blood vessels supplying the penis which allows increased blood and oxygen supply, thereby improving its functions.

Common side effects of Dapoxetine+Tadalafil

• dizziness, headache
• back pain, muscle pain, pain in arms and legs
• nausea, vomiting
• feeling irritable, anxious, agitated, or restless
• sensation of numbness, tingling or prickling
• increased sweating
• hot flushes
• diarrhea, constipation, wind, stomach pain, indigestion
• problems in sleeping or strange dreams, difficulty in concentration
• tiredness or sleepiness
• blocked nose
• a rise in blood pressure
• decrease in sex drive
• ringing in the ears
• blurred vision, color tinge to vision, visual disturbance
• dry mouth

When to consult your doctor

Consult your doctor if you experience:

• prolonged or painful erection (priapism)
• chest pain
• sudden decline or loss of vision
• fits or seizures
• fainting or light headedness while standing
• mood changes, suicidal thoughts, or a tendency for self-harming

Health Tips for Dapoxetine+Tadalafil

• Take Dapoxetine + Tadalafil preferably before meals. Follow the dosing schedule as advised by your physician. Do not take this medicine for a longer period than advised by your doctor
• Avoid taking Dapoxetine + Tadalafil with grapefruit juice, as it may reduce the effectiveness of this medicine or may create unpleasant side effects
• Dapoxetine + Tadalafil can cause excessive dizziness or drowsiness. Therefore, do not drive or perform any activities that require complete concentration. Avoid consumption of alcohol as it could aggravate your dizziness
• Before taking this medicine, inform your doctor if you have any previous history of fainting or dizziness due to low blood pressure
• You must also inform your doctor if you have epilepsy, lung problems, mental health problems, or bleeding disorders as a precaution

Almanacilic>Tadalafil for Men* The brand name of this product is 'Dapoxetine' is not available. See the end of this leaflet for possible brand and generic details

Brand	Substance	Manufacturer	Prescription required	Review
Almanilic®	Dapoxetine	No
Dapoxetine + Tadalafil	Manufactured by Janssen-Cilag

What is Dapoxetine?

It works by increasing the activity of a chemical called serotonin in the brain.

Tadalafil is a PD-1 inhibitor. It increases the activity of a substance called cyclic guanosine monophosphate (cGMP), resulting in increased blood flow to the penis. This increased blood flow improves the chances of achieving and maintaining an erection.

Dapoxetine+sildenafil is used in the treatment of premature ejaculation and erectile dysfunction in adult men. Premature ejaculation is when a man ejaculates (orgasms) more quickly with less sexual stimulation than the man or his partner would like. This could lead to problems in a sexual relationship. Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity.

Dapoxetine+sildenafil contains Dapoxetine and Sildenafil. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that increases the serotonin levels in the brain, thereby increasing the time to ejaculate and improving the control over ejaculation. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor and works by relaxing the blood vessels. It can improve blood flow to the penis and helps to get an erection when sexually stimulated.

You should use this medicine exactly as prescribed by the doctor. The common side-effects of Dapoxetine+sildenafil are dizziness, headache, nausea (feeling sick), stuffy nose, facial flushing (reddening of the face), indigestion, dry mouth, and vision problems such as light sensitivity or blurred vision. These side effects usually resolve without requiring medical attention. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Dapoxetine+sildenafil if you are allergic to any contents of it. Do not take Dapoxetine+sildenafil if you have severe heart or liver problems, a recent history of heart attack or stroke, hypotension (low blood pressure), eye diseases or vision problems, a history of fainting, and mania or depression. Inform your doctor if you are taking medicines such as nitrates (to treat blood pressure or chest pain), antidepressants, antibiotics, or painkillers. Dapoxetine+sildenafil should not be taken by children and women. It should be used with caution in the elderly. Do not take excessive amounts of alcohol while using Dapoxetine+sildenafil as it may impair the ability of erection and increase the risk of side effects. Dapoxetine+sildenafil may cause dizziness and affect vision, so do not drive or operate heavy machinery if you are not fully alert.

Next, take one tablet at bedtime to be taken without milk. If you take extra tablets to take it at regular times, you may experience delayed ejaculation. Take Dapoxetine+sildenafil with a large meal (over an hour) to get the best absorption. Avoid taking extra tablets to take Dapoxetine+sildenafil so that daily consumption is not carried to the next day. Avoid consuming large amounts of alcohol while taking Dapoxetine+sildenafil as it may cause mildic dyspareunia (abnormal ejaculation with no cause) and enhance the risk of vision problems. Dapoxetine+sildenafil should be used only if required by the doctor. Do not take it while you are pregnant or taking any breastfeeding precautionary measure. It may harm your baby if it is taken by breastfeeding mothers.If you take Dapoxetine+sildenafil, you must be very cautious while using it. Avoid drinking too much alcohol while taking it, as it may cause dizziness or affect vision, so do not drive or operate heavy machinery if you are not fully alert. Avoid eating certain foods, such as grapefruit, grapefruit juice, marijuana, macadamol, or onion, as they can make symptoms of dizziness worse. It may interfere with the effect of Dapoxetine+sildenafil and cause visual problems, so do not take it if you take certain foods into your meals. It may cause headaches and may affect vision. If you take Dapoxetine+sildenafil, do not take it while you are taking, as it may affect the ability of erection and increase the possible side effects such as difficulty in achieving and maintaining an erection, pain in the testicles, headache, and vaginal dryness. Before taking this medicine, be sure your doctor is informed about all the conditions that may interact with it. If you are taking any of the medicines for the treatment of HIV, do not take Dapoxetine+sildenafil without consulting your doctor.

Dapoxetine:Used in adult males to treat premature ejaculation (PE), it is used to increase the control over ejaculation. It works by inhibiting the serotonin transporter, increasing serotonin's action at the post-synaptic cleft, and facilitating ejaculatory delay.

Dapoxetine is not approved for use by the FDA or other medical providers. It may interact with other medications or supplements. It is not suitable for use in women or children. It is not a recommended starting dose for all patients.

It is not recommended for use in women or children. It is not suitable for use in men.

Dapoxetine is not approved for use in women or children.

Dapoxetine may interact with other medications or supplements. It is not approved for use in women or children.

Dapoxetine

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It is not recommended for use in women.

Brand Names

Dapoxetine is a prescription medication used to treat premature ejaculation (PE) in adult males, and is available for use in adult males.

Uses

Dapoxetine is used for the treatment of premature ejaculation. It is used to increase the control over ejaculation in adult males who have experienced premature ejaculation (PE) or have a family history of premature ejaculation (PE) in any other family members.

Warnings

Dapoxetine should not be used by men who are planning to have sex and are taking other medications that may interact with Dapoxetine. It is not recommended for use by men who are taking other medications that may interact with Dapoxetine.